Modeling and simulation of cardiac tissue using hybrid I/O automata

We propose a new biological framework based on the Lynch et al. theory of Hybrid I/O Automata (HIOAs) for modeling and simulating excitable tissue. Within this framework, we view an excitable tissue as a composition of two main kinds of component: a diffusion medium and a collection of cells, both modeled as an HIOA. This approach yields a notion of decomposition that allows us to describe a tissue as the parallel composition of several interacting tissues, a property that could be exploited to parallelize, and hence improve, the efficiency of the simulation process. We also demonstrate the feasibility of ourHIOA-based framework to capture andmimic different kinds of wave-propagation behavior in 2D isotropic cardiac tissue, including normal wave propagation along the tissue; the creation of spiral waves; the break-up of spiral waves into more complex patterns such as fibrillation; and the recovery of the tissue to the rest via electrical defibrillation. © 2009 Elsevier B.V. All rights reserved.